Drug interactions
Glycopyrrolate + Trazodone
Severity: Minor
Glycopyrrolate and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrrolate is a peripherally acting antimuscarinic and trazodone has weak anticholinergic properties. Combined use may add to dry mouth, constipation or urinary retention, though the effect is usually mild.
What this interaction means in plain words
Glycopyrrolate and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrrolate belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Additive peripheral anticholinergic effects.
What to do
Monitor for anticholinergic symptoms, especially in elderly patients or those with urinary retention. Adjust glycopyrrolate dose if bothersome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Trazodone?
MediHelp rates the interaction as minor. Glycopyrrolate and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycopyrrolate is a peripherally acting antimuscarinic and trazodone has weak anticholinergic properties. Combined use may add to dry mouth, constipation or urinary retention, though the effect is usually mild.
How serious is the interaction between Glycopyrrolate and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially in elderly patients or those with urinary retention. Adjust glycopyrrolate dose if bothersome.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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