Drug interactions
Glycopyrronium + Haloperidol
Severity: Minor
Glycopyrronium and Haloperidol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has weak anticholinergic activity, so additive effects with glycopyrronium are generally modest but may still cause dry mouth, constipation or urinary retention. Antimuscarinics are sometimes used deliberately to counter haloperidol extrapyramidal effects.
What this interaction means in plain words
Glycopyrronium and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrronium belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Mild additive antimuscarinic effects.
What to do
Monitor for anticholinergic symptoms such as constipation and urinary retention; no dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Glycopyrronium with Haloperidol?
MediHelp rates the interaction as minor. Glycopyrronium and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol has weak anticholinergic activity, so additive effects with glycopyrronium are generally modest but may still cause dry mouth, constipation or urinary retention. Antimuscarinics are sometimes used deliberately to counter haloperidol extrapyramidal effects.
How serious is the interaction between Glycopyrronium and Haloperidol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms such as constipation and urinary retention; no dose change is usually needed.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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