Drug interactions
Glycopyrronium + Iloperidone
Severity: Moderate
Glycopyrronium and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has modest antimuscarinic activity and may add to glycopyrronium effects such as constipation, dry mouth and urinary retention. Iloperidone also prolongs the QT interval.
What this interaction means in plain words
Glycopyrronium and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects; iloperidone has independent QT-prolonging effects.
What to do
Monitor for anticholinergic effects such as constipation and urinary retention. Check ECG and electrolytes if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glycopyrronium with Iloperidone?
MediHelp rates the interaction as moderate. Glycopyrronium and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has modest antimuscarinic activity and may add to glycopyrronium effects such as constipation, dry mouth and urinary retention. Iloperidone also prolongs the QT interval.
How serious is the interaction between Glycopyrronium and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation and urinary retention. Check ECG and electrolytes if other QT risk factors are present.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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