Drug interactions
Glycopyrronium + Revefenacin
Severity: Moderate
Glycopyrronium and Revefenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is an inhaled long-acting muscarinic antagonist and glycopyrronium is an antimuscarinic. Combined use may increase anticholinergic adverse effects such as dry mouth, urinary retention, constipation and raised intraocular pressure.
What this interaction means in plain words
Glycopyrronium and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Revefenacin belongs to Respiratory.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Avoid combining with other anticholinergic bronchodilators where possible. If both are required, monitor for urinary retention, glaucoma symptoms and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Glycopyrronium with Revefenacin?
MediHelp rates the interaction as moderate. Glycopyrronium and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is an inhaled long-acting muscarinic antagonist and glycopyrronium is an antimuscarinic. Combined use may increase anticholinergic adverse effects such as dry mouth, urinary retention, constipation and raised intraocular pressure.
How serious is the interaction between Glycopyrronium and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with other anticholinergic bronchodilators where possible. If both are required, monitor for urinary retention, glaucoma symptoms and constipation.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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