Drug interactions
Glycopyrronium + Solifenacin
Severity: Moderate
Glycopyrronium and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so their effects add together, producing dry mouth, constipation, blurred vision and urinary retention. The risk is greater in older adults and in those with narrow-angle glaucoma or reduced bowel motility.
What this interaction means in plain words
Glycopyrronium and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrronium belongs to Respiratory; Solifenacin belongs to Genitourinary.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Avoid combining if possible; if both are needed, monitor for anticholinergic effects and post-void residual urine and reduce doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Solifenacin
Frequently asked questions
Can I take Glycopyrronium with Solifenacin?
MediHelp rates the interaction as moderate. Glycopyrronium and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so their effects add together, producing dry mouth, constipation, blurred vision and urinary retention. The risk is greater in older adults and in those with narrow-angle glaucoma or reduced bowel motility.
How serious is the interaction between Glycopyrronium and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; if both are needed, monitor for anticholinergic effects and post-void residual urine and reduce doses as needed.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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