Drug interactions
Goserelin + Ibutilide
Severity: Major
Goserelin and Ibutilide: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide carries a high risk of torsades de pointes, and goserelin may add QT prolongation. The pairing increases the chance of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Goserelin and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Goserelin belongs to Endocrine; Ibutilide belongs to Cardiovascular.
Why it happens
Additive QT prolongation: ibutilide blocks IKr and androgen deprivation may prolong repolarization.
What to do
Use continuous ECG monitoring during and after ibutilide administration and ensure normal potassium and magnesium. Avoid ibutilide if the baseline QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Goserelin and Ibutilide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Goserelin
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Goserelin with Ibutilide?
MediHelp rates the interaction as major. Goserelin and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide carries a high risk of torsades de pointes, and goserelin may add QT prolongation. The pairing increases the chance of life-threatening ventricular arrhythmia.
How serious is the interaction between Goserelin and Ibutilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous ECG monitoring during and after ibutilide administration and ensure normal potassium and magnesium. Avoid ibutilide if the baseline QTc is prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
