Drug interactions
Goserelin + Levofloxacin
Severity: Moderate
Goserelin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with goserelin can prolong the QT interval, and levofloxacin adds to the effect. The combination may increase the risk of torsades de pointes in men with cardiac risk factors.
What this interaction means in plain words
Goserelin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with androgen suppression altering cardiac repolarization.
What to do
Check a baseline ECG and electrolytes and prefer a non-QT-prolonging antibiotic. If levofloxacin is needed, monitor the QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Levofloxacin?
MediHelp rates the interaction as moderate. Goserelin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with goserelin can prolong the QT interval, and levofloxacin adds to the effect. The combination may increase the risk of torsades de pointes in men with cardiac risk factors.
How serious is the interaction between Goserelin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and prefer a non-QT-prolonging antibiotic. If levofloxacin is needed, monitor the QTc.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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