Drug interactions
Goserelin + Memantine-donepezil
Severity: Moderate
Goserelin and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and donepezil may add to this effect. The clinical risk is usually modest but matters in patients with heart disease.
What this interaction means in plain words
Goserelin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and electrolytes in patients with cardiac risk factors. Monitor the QTc periodically during co-treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Memantine-donepezil?
MediHelp rates the interaction as moderate. Goserelin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and donepezil may add to this effect. The clinical risk is usually modest but matters in patients with heart disease.
How serious is the interaction between Goserelin and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes in patients with cardiac risk factors. Monitor the QTc periodically during co-treatment.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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