Drug interactions
Goserelin + Sertraline
Severity: Moderate
Goserelin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin may prolong the QT interval, and sertraline has a small additive effect. The risk of torsades de pointes is mainly relevant in patients with other risk factors.
What this interaction means in plain words
Goserelin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors and repeat if other QT-prolonging drugs are added. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Sertraline?
MediHelp rates the interaction as moderate. Goserelin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin may prolong the QT interval, and sertraline has a small additive effect. The risk of torsades de pointes is mainly relevant in patients with other risk factors.
How serious is the interaction between Goserelin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors and repeat if other QT-prolonging drugs are added. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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