Drug interactions
Goserelin + Tetrabenazine
Severity: Moderate
Goserelin and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes modest QT prolongation, and goserelin may contribute further. The combination can increase arrhythmia risk, particularly at higher tetrabenazine doses.
What this interaction means in plain words
Goserelin and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation from androgen deprivation (goserelin) and tetrabenazine effects on cardiac repolarization.
What to do
Check a baseline ECG and monitor the QTc after starting the combination. Avoid it in patients with congenital long QT syndrome or a history of arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Goserelin and Tetrabenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Goserelin
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Goserelin with Tetrabenazine?
MediHelp rates the interaction as moderate. Goserelin and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes modest QT prolongation, and goserelin may contribute further. The combination can increase arrhythmia risk, particularly at higher tetrabenazine doses.
How serious is the interaction between Goserelin and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor the QTc after starting the combination. Avoid it in patients with congenital long QT syndrome or a history of arrhythmia.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
