Drug interactions
Granisetron + Itraconazole
Severity: Moderate
Granisetron and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may prolong the QT interval and strongly inhibits CYP3A4, which contributes to granisetron metabolism. The combination may increase granisetron exposure and add to QT effects.
What this interaction means in plain words
Granisetron and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition that may increase granisetron concentrations.
What to do
Monitor the ECG and electrolytes, especially with other QT-prolonging drugs or heart failure. Use the lowest effective granisetron dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Granisetron with Itraconazole?
MediHelp rates the interaction as moderate. Granisetron and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may prolong the QT interval and strongly inhibits CYP3A4, which contributes to granisetron metabolism. The combination may increase granisetron exposure and add to QT effects.
How serious is the interaction between Granisetron and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes, especially with other QT-prolonging drugs or heart failure. Use the lowest effective granisetron dose.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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