Drug interactions
Granisetron + Moxifloxacin
Severity: Major
Granisetron and Moxifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is a fluoroquinolone with well-documented QT prolongation, and granisetron adds a small additional effect. The combination increases the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Granisetron and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Granisetron belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT interval prolongation.
What to do
Use an antibiotic with less QT effect where possible. If both are needed, check a baseline ECG and electrolytes and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Granisetron with Moxifloxacin?
MediHelp rates the interaction as major. Granisetron and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Moxifloxacin is a fluoroquinolone with well-documented QT prolongation, and granisetron adds a small additional effect. The combination increases the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Granisetron and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antibiotic with less QT effect where possible. If both are needed, check a baseline ECG and electrolytes and monitor the QTc.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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