Drug interactions
Granisetron + Osimertinib
Severity: Moderate
Granisetron and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval, and granisetron may contribute additively. The clinical risk is modest but relevant in patients with electrolyte abnormalities or other QT-prolonging therapy.
What this interaction means in plain words
Granisetron and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Monitor the ECG and electrolytes periodically and correct abnormalities. Use an alternative antiemetic if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Granisetron with Osimertinib?
MediHelp rates the interaction as moderate. Granisetron and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval, and granisetron may contribute additively. The clinical risk is modest but relevant in patients with electrolyte abnormalities or other QT-prolonging therapy.
How serious is the interaction between Granisetron and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes periodically and correct abnormalities. Use an alternative antiemetic if the QTc becomes prolonged.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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