Drug interactions
Granisetron + Vemurafenib
Severity: Moderate
Granisetron and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way, and granisetron may add to this. Patients with electrolyte abnormalities or heart disease are at greater risk.
What this interaction means in plain words
Granisetron and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Vemurafenib belongs to Oncology.
Why it happens
Additive prolongation of the QT interval.
What to do
Monitor ECG and electrolytes, and correct abnormalities. Consider an alternative antiemetic if the QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Granisetron with Vemurafenib?
MediHelp rates the interaction as moderate. Granisetron and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QT interval in a concentration-dependent way, and granisetron may add to this. Patients with electrolyte abnormalities or heart disease are at greater risk.
How serious is the interaction between Granisetron and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and correct abnormalities. Consider an alternative antiemetic if the QTc rises.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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