Drug interactions
Granisetron + Voriconazole
Severity: Moderate
Granisetron and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can prolong the QT interval and granisetron has a comparable effect, so concurrent use may increase risk of torsades de pointes. Voriconazole also inhibits CYP3A4, which contributes to granisetron metabolism and may modestly raise its exposure.
What this interaction means in plain words
Granisetron and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, possibly with reduced CYP3A4-mediated clearance of granisetron.
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium. Monitor the QTc during combined therapy, particularly in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Granisetron with Voriconazole?
MediHelp rates the interaction as moderate. Granisetron and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can prolong the QT interval and granisetron has a comparable effect, so concurrent use may increase risk of torsades de pointes. Voriconazole also inhibits CYP3A4, which contributes to granisetron metabolism and may modestly raise its exposure.
How serious is the interaction between Granisetron and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium. Monitor the QTc during combined therapy, particularly in patients with other risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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