Drug interactions
Grapefruit + Silodosin
Severity: Minor
Grapefruit and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may somewhat increase silodosin exposure. Clinical data are limited and the effect is probably small. Excess exposure could cause dizziness and orthostatic hypotension.
What this interaction means in plain words
Grapefruit and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Grapefruit components inhibit intestinal CYP3A4, reducing first-pass metabolism of silodosin.
What to do
Advise patients to avoid large amounts of grapefruit juice and to report dizziness on standing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Grapefruit and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Grapefruit with Silodosin?
MediHelp rates the interaction as minor. Grapefruit and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may somewhat increase silodosin exposure. Clinical data are limited and the effect is probably small. Excess exposure could cause dizziness and orthostatic hypotension.
How serious is the interaction between Grapefruit and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid large amounts of grapefruit juice and to report dizziness on standing.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
