Drug interactions
Griseofulvin + Maraviroc
Severity: Moderate
Griseofulvin and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and strong inducers require dose increases. Griseofulvin is a weaker inducer but may still lower maraviroc exposure and reduce antiviral efficacy.
What this interaction means in plain words
Griseofulvin and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Maraviroc belongs to Anti Virals.
Why it happens
CYP3A4 induction by griseofulvin increases maraviroc clearance.
What to do
Monitor HIV viral load and consider maraviroc levels. Adjust the dose per labeling if inducer effect is confirmed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Griseofulvin and Maraviroc, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Griseofulvin
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Griseofulvin with Maraviroc?
MediHelp rates the interaction as moderate. Griseofulvin and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate, and strong inducers require dose increases. Griseofulvin is a weaker inducer but may still lower maraviroc exposure and reduce antiviral efficacy.
How serious is the interaction between Griseofulvin and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider maraviroc levels. Adjust the dose per labeling if inducer effect is confirmed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
