Drug interactions
Griseofulvin + Pacritinib
Severity: Moderate
Griseofulvin and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is mainly metabolized by CYP3A4, and griseofulvin is a CYP3A4 inducer. Lower pacritinib exposure could reduce efficacy.
What this interaction means in plain words
Griseofulvin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Pacritinib belongs to Oncology.
Why it happens
Griseofulvin induces CYP3A4, increasing pacritinib clearance.
What to do
Monitor for loss of pacritinib response, including spleen size and symptoms. Prefer an alternative antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Griseofulvin with Pacritinib?
MediHelp rates the interaction as moderate. Griseofulvin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is mainly metabolized by CYP3A4, and griseofulvin is a CYP3A4 inducer. Lower pacritinib exposure could reduce efficacy.
How serious is the interaction between Griseofulvin and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pacritinib response, including spleen size and symptoms. Prefer an alternative antifungal if feasible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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