Drug interactions
Guanfacine + Sotalol
Severity: Moderate
Guanfacine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower heart rate and blood pressure, so additive hypotension and bradycardia can occur. If guanfacine is stopped abruptly during beta-blocker therapy, rebound hypertension may be exaggerated.
What this interaction means in plain words
Guanfacine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive sympatholytic effects; beta-blockade leaves alpha stimulation unopposed during central alpha-agonist withdrawal.
What to do
Monitor blood pressure and heart rate. If stopping both, withdraw the beta-blocker first and taper guanfacine gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Sotalol?
MediHelp rates the interaction as moderate. Guanfacine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower heart rate and blood pressure, so additive hypotension and bradycardia can occur. If guanfacine is stopped abruptly during beta-blocker therapy, rebound hypertension may be exaggerated.
How serious is the interaction between Guanfacine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate. If stopping both, withdraw the beta-blocker first and taper guanfacine gradually.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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