Drug interactions
Haloperidol + Iloperidone
Severity: Major
Haloperidol and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics that prolong the QT interval, and combined use also adds extrapyramidal, sedative and neuroleptic malignant syndrome risks. Haloperidol inhibits CYP2D6 and can raise iloperidone exposure further.
What this interaction means in plain words
Haloperidol and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and dopamine blockade, with CYP2D6 inhibition by haloperidol increasing iloperidone levels.
What to do
Avoid antipsychotic polypharmacy where possible. If used together, monitor ECG and electrolytes, watch for extrapyramidal symptoms and sedation, and consider reducing the iloperidone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Haloperidol with Iloperidone?
MediHelp rates the interaction as major. Haloperidol and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are antipsychotics that prolong the QT interval, and combined use also adds extrapyramidal, sedative and neuroleptic malignant syndrome risks. Haloperidol inhibits CYP2D6 and can raise iloperidone exposure further.
How serious is the interaction between Haloperidol and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If used together, monitor ECG and electrolytes, watch for extrapyramidal symptoms and sedation, and consider reducing the iloperidone dose.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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