Drug interactions
Haloperidol + Ivabradine
Severity: Major
Haloperidol and Ivabradine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval, and bradycardia from ivabradine increases torsades risk. Haloperidol also has minor CYP3A4 inhibition.
What this interaction means in plain words
Haloperidol and Ivabradine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Ivabradine belongs to Cardiovascular.
Why it happens
Additive proarrhythmic effects: QT prolongation by haloperidol with ivabradine-induced bradycardia.
What to do
Check baseline ECG, potassium and magnesium, and monitor heart rate and QTc. Consider an alternative antipsychotic if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Ivabradine?
MediHelp rates the interaction as major. Haloperidol and Ivabradine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol prolongs the QT interval, and bradycardia from ivabradine increases torsades risk. Haloperidol also has minor CYP3A4 inhibition.
How serious is the interaction between Haloperidol and Ivabradine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium and magnesium, and monitor heart rate and QTc. Consider an alternative antipsychotic if QTc is prolonged.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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