Drug interactions
Haloperidol + Ivacaftor
Severity: Minor
Haloperidol and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A4 substrate, but haloperidol is at most a weak CYP3A4 inhibitor, so a meaningful increase in ivacaftor exposure is unlikely.
What this interaction means in plain words
Haloperidol and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Ivacaftor belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol.
What to do
No dose change is generally needed; monitor for ivacaftor adverse effects such as elevated liver enzymes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Haloperidol with Ivacaftor?
MediHelp rates the interaction as minor. Haloperidol and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a CYP3A4 substrate, but haloperidol is at most a weak CYP3A4 inhibitor, so a meaningful increase in ivacaftor exposure is unlikely.
How serious is the interaction between Haloperidol and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for ivacaftor adverse effects such as elevated liver enzymes.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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