Drug interactions
Haloperidol + Letermovir
Severity: Moderate
Haloperidol and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 moderately, which can raise haloperidol exposure since CYP3A4 is one of its metabolic routes. Higher haloperidol levels may increase extrapyramidal symptoms, sedation and QT prolongation.
What this interaction means in plain words
Haloperidol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated haloperidol metabolism by letermovir.
What to do
Monitor for extrapyramidal symptoms, sedation and QTc changes while both drugs are given. Reduce the haloperidol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Haloperidol with Letermovir?
MediHelp rates the interaction as moderate. Haloperidol and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 moderately, which can raise haloperidol exposure since CYP3A4 is one of its metabolic routes. Higher haloperidol levels may increase extrapyramidal symptoms, sedation and QT prolongation.
How serious is the interaction between Haloperidol and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QTc changes while both drugs are given. Reduce the haloperidol dose if adverse effects appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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