Drug interactions
Haloperidol + Levomilnacipran
Severity: Moderate
Haloperidol and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an antipsychotic with a serotonin-norepinephrine reuptake inhibitor may increase the risk of serotonin toxicity or neuroleptic malignant syndrome, although both are uncommon. Levomilnacipran can also raise blood pressure and heart rate, and haloperidol adds some QT risk.
What this interaction means in plain words
Haloperidol and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic modulation, with haloperidol blocking dopamine receptors while levomilnacipran increases synaptic serotonin and norepinephrine.
What to do
Monitor for agitation, tremor, hyperthermia, rigidity and autonomic instability, particularly when starting or increasing doses. Stop the offending drugs and give supportive care if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Haloperidol with Levomilnacipran?
MediHelp rates the interaction as moderate. Haloperidol and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an antipsychotic with a serotonin-norepinephrine reuptake inhibitor may increase the risk of serotonin toxicity or neuroleptic malignant syndrome, although both are uncommon. Levomilnacipran can also raise blood pressure and heart rate, and haloperidol adds some QT risk.
How serious is the interaction between Haloperidol and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, rigidity and autonomic instability, particularly when starting or increasing doses. Stop the offending drugs and give supportive care if serotonin syndrome or NMS is suspected.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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