Drug interactions
Haloperidol + Lomitapide
Severity: Moderate
Haloperidol and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate and haloperidol is a weak CYP3A4 inhibitor, so lomitapide exposure may rise. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Haloperidol is itself a weaker inhibitor than the strong and moderate inhibitors that are formally contraindicated.
What this interaction means in plain words
Haloperidol and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Haloperidol weakly inhibits CYP3A4, reducing the first-pass and systemic clearance of lomitapide.
What to do
Monitor liver enzymes and gastrointestinal tolerability, and consider reducing the lomitapide dose per labeling for weak inhibitors. Reassess the lipid-lowering plan if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Haloperidol with Lomitapide?
MediHelp rates the interaction as moderate. Haloperidol and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate and haloperidol is a weak CYP3A4 inhibitor, so lomitapide exposure may rise. Higher lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. Haloperidol is itself a weaker inhibitor than the strong and moderate inhibitors that are formally contraindicated.
How serious is the interaction between Haloperidol and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability, and consider reducing the lomitapide dose per labeling for weak inhibitors. Reassess the lipid-lowering plan if transaminases rise.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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