Drug interactions
Haloperidol + Lonafarnib
Severity: Moderate
Haloperidol and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, and haloperidol has only weak CYP3A4 inhibitory activity. A modest rise in lonafarnib exposure is possible, which may worsen gastrointestinal effects and other dose-related toxicity. Lonafarnib itself can also prolong the QT interval.
What this interaction means in plain words
Haloperidol and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Haloperidol weakly inhibits CYP3A4, which may modestly raise lonafarnib concentrations, and both drugs have potential QT effects.
What to do
Monitor for lonafarnib adverse effects and obtain an ECG if other QT risk factors are present. Correct electrolyte disturbances and consider lowering the lonafarnib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Haloperidol with Lonafarnib?
MediHelp rates the interaction as moderate. Haloperidol and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A4 substrate, and haloperidol has only weak CYP3A4 inhibitory activity. A modest rise in lonafarnib exposure is possible, which may worsen gastrointestinal effects and other dose-related toxicity. Lonafarnib itself can also prolong the QT interval.
How serious is the interaction between Haloperidol and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects and obtain an ECG if other QT risk factors are present. Correct electrolyte disturbances and consider lowering the lonafarnib dose if toxicity occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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