Drug interactions
Haloperidol + Lurasidone
Severity: Moderate
Haloperidol and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics adds dopamine blockade, increasing the risk of extrapyramidal symptoms, sedation and rarely neuroleptic malignant syndrome. Haloperidol may also contribute modest QT effects.
What this interaction means in plain words
Haloperidol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive D2 receptor antagonism and CNS depressant effects.
What to do
Avoid concurrent use unless clearly justified, using the lowest effective doses. Monitor for extrapyramidal symptoms, sedation and signs of neuroleptic malignant syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Haloperidol with Lurasidone?
MediHelp rates the interaction as moderate. Haloperidol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics adds dopamine blockade, increasing the risk of extrapyramidal symptoms, sedation and rarely neuroleptic malignant syndrome. Haloperidol may also contribute modest QT effects.
How serious is the interaction between Haloperidol and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless clearly justified, using the lowest effective doses. Monitor for extrapyramidal symptoms, sedation and signs of neuroleptic malignant syndrome.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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