Drug interactions
Haloperidol + Macimorelin
Severity: Major
Haloperidol and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT prolongation and haloperidol also prolongs QT, so the combination may raise the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Haloperidol and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Avoid giving macimorelin to patients taking haloperidol and allow adequate washout of haloperidol before testing where clinically possible. Otherwise use an alternative growth hormone stimulation test.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Haloperidol with Macimorelin?
MediHelp rates the interaction as major. Haloperidol and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT prolongation and haloperidol also prolongs QT, so the combination may raise the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Haloperidol and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin to patients taking haloperidol and allow adequate washout of haloperidol before testing where clinically possible. Otherwise use an alternative growth hormone stimulation test.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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