Drug interactions
Haloperidol + Midazolam
Severity: Minor
Haloperidol and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is at most a weak CYP3A4 inhibitor, so any rise in midazolam levels is small. The combination has additive sedation, but a meaningful pharmacokinetic interaction is not well established.
What this interaction means in plain words
Haloperidol and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol, plus additive CNS depression.
What to do
Monitor sedation level and respiratory status when both are given, for example in agitation management.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Midazolam?
MediHelp rates the interaction as minor. Haloperidol and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is at most a weak CYP3A4 inhibitor, so any rise in midazolam levels is small. The combination has additive sedation, but a meaningful pharmacokinetic interaction is not well established.
How serious is the interaction between Haloperidol and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status when both are given, for example in agitation management.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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