Drug interactions
Haloperidol + Moxifloxacin
Severity: Major
Haloperidol and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and moxifloxacin each lengthen the QT interval, and together they raise the likelihood of torsades de pointes. Risk is higher with intravenous haloperidol, high doses, electrolyte imbalance or structural heart disease.
What this interaction means in plain words
Haloperidol and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive hERG potassium channel blockade leading to delayed ventricular repolarization.
What to do
Choose an antibiotic without QT effects if feasible. Otherwise check a baseline and follow-up ECG, correct hypokalemia and hypomagnesemia, and use the lowest effective haloperidol dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Moxifloxacin?
MediHelp rates the interaction as major. Haloperidol and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol and moxifloxacin each lengthen the QT interval, and together they raise the likelihood of torsades de pointes. Risk is higher with intravenous haloperidol, high doses, electrolyte imbalance or structural heart disease.
How serious is the interaction between Haloperidol and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an antibiotic without QT effects if feasible. Otherwise check a baseline and follow-up ECG, correct hypokalemia and hypomagnesemia, and use the lowest effective haloperidol dose.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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