Drug interactions
Haloperidol + Nabilone
Severity: Moderate
Haloperidol and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so concurrent use can increase sedation and impair coordination and alertness. Cannabinoids may also exacerbate psychosis or cause anxiety and tachycardia in susceptible patients.
What this interaction means in plain words
Haloperidol and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression through cannabinoid receptor agonism and dopamine D2 antagonism.
What to do
Monitor sedation, heart rate and psychiatric symptoms, particularly in patients with psychotic disorders. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Nabilone?
MediHelp rates the interaction as moderate. Haloperidol and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so concurrent use can increase sedation and impair coordination and alertness. Cannabinoids may also exacerbate psychosis or cause anxiety and tachycardia in susceptible patients.
How serious is the interaction between Haloperidol and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and psychiatric symptoms, particularly in patients with psychotic disorders. Use the lowest effective doses.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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