Drug interactions
Haloperidol + Osilodrostat
Severity: Major
Haloperidol and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which further increases arrhythmia risk.
What this interaction means in plain words
Haloperidol and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation, with osilodrostat-related hypokalemia as an aggravating factor.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor ECG and electrolytes. Consider an alternative antipsychotic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Haloperidol with Osilodrostat?
MediHelp rates the interaction as major. Haloperidol and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which further increases arrhythmia risk.
How serious is the interaction between Haloperidol and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor ECG and electrolytes. Consider an alternative antipsychotic if the QTc becomes markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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