Drug interactions
Haloperidol + Osimertinib
Severity: Major
Haloperidol and Osimertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, and combined use can increase the risk of serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Haloperidol and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarisation.
What to do
Perform periodic ECG monitoring and keep potassium and magnesium within normal range. Avoid the combination if the QTc becomes markedly prolonged and consider alternatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Haloperidol with Osimertinib?
MediHelp rates the interaction as major. Haloperidol and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are associated with QT prolongation, and combined use can increase the risk of serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Haloperidol and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and keep potassium and magnesium within normal range. Avoid the combination if the QTc becomes markedly prolonged and consider alternatives.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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