Drug interactions
Haloperidol + Oxaliplatin
Severity: Major
Haloperidol and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol and oxaliplatin can each prolong the QT interval. Oxaliplatin-related vomiting, diarrhea and electrolyte loss can further increase the risk of torsades de pointes.
What this interaction means in plain words
Haloperidol and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation, compounded by chemotherapy-induced hypokalemia and hypomagnesemia.
What to do
Check ECG and electrolytes before and during treatment, and replace potassium and magnesium as needed. Prefer a non-QT-prolonging antiemetic or antipsychotic where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Haloperidol with Oxaliplatin?
MediHelp rates the interaction as major. Haloperidol and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol and oxaliplatin can each prolong the QT interval. Oxaliplatin-related vomiting, diarrhea and electrolyte loss can further increase the risk of torsades de pointes.
How serious is the interaction between Haloperidol and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during treatment, and replace potassium and magnesium as needed. Prefer a non-QT-prolonging antiemetic or antipsychotic where possible.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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