Drug interactions
Haloperidol + Rilpivirine
Severity: Moderate
Haloperidol and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval and carries a known risk of torsades de pointes. Rilpivirine at higher than standard doses also prolongs QT, so the combination may add to arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Haloperidol and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive blockade of cardiac potassium channels (hERG) leading to QTc prolongation.
What to do
Obtain a baseline ECG and monitor QTc during co-therapy, and correct hypokalemia and hypomagnesemia. Consider an alternative antipsychotic or antiretroviral if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Haloperidol with Rilpivirine?
MediHelp rates the interaction as moderate. Haloperidol and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol prolongs the QT interval and carries a known risk of torsades de pointes. Rilpivirine at higher than standard doses also prolongs QT, so the combination may add to arrhythmia risk, especially with other risk factors.
How serious is the interaction between Haloperidol and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during co-therapy, and correct hypokalemia and hypomagnesemia. Consider an alternative antipsychotic or antiretroviral if QTc becomes markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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