Drug interactions
Haloperidol + Selinexor
Severity: Moderate
Haloperidol and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion, fatigue and other neurological effects. Haloperidol can add sedation, dizziness and extrapyramidal effects, which may increase the risk of falls and cognitive impairment.
What this interaction means in plain words
Haloperidol and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion, sedation and falls, and reduce the haloperidol dose or review the need for it if neurological toxicity develops. Counsel patients to avoid driving and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Haloperidol with Selinexor?
MediHelp rates the interaction as moderate. Haloperidol and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion, fatigue and other neurological effects. Haloperidol can add sedation, dizziness and extrapyramidal effects, which may increase the risk of falls and cognitive impairment.
How serious is the interaction between Haloperidol and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion, sedation and falls, and reduce the haloperidol dose or review the need for it if neurological toxicity develops. Counsel patients to avoid driving and hazardous activities.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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