Drug interactions
Haloperidol + Sonidegib
Severity: Minor
Haloperidol and Sonidegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is not a recognized meaningful CYP3A4 inhibitor, so the effect on sonidegib exposure is likely small. Sonidegib can cause musculoskeletal toxicity and CK elevation, which would be the concern if exposure increased.
What this interaction means in plain words
Haloperidol and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Sonidegib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol could slightly reduce sonidegib clearance; this is not well established.
What to do
No dose adjustment is needed. Monitor for muscle pain, weakness and CK elevation as part of routine sonidegib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Haloperidol with Sonidegib?
MediHelp rates the interaction as minor. Haloperidol and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is not a recognized meaningful CYP3A4 inhibitor, so the effect on sonidegib exposure is likely small. Sonidegib can cause musculoskeletal toxicity and CK elevation, which would be the concern if exposure increased.
How serious is the interaction between Haloperidol and Sonidegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for muscle pain, weakness and CK elevation as part of routine sonidegib care.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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