Drug interactions
Haloperidol + Tazemetostat
Severity: Moderate
Haloperidol and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized by CYP3A4, and haloperidol can modestly inhibit this enzyme. Higher tazemetostat exposure could increase its adverse effects. The clinical magnitude is likely smaller than with established moderate inhibitors.
What this interaction means in plain words
Haloperidol and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Haloperidol inhibits CYP3A4, decreasing tazemetostat metabolism.
What to do
Monitor for tazemetostat toxicity, or choose an antipsychotic without CYP3A4 inhibition. If a labeled CYP3A4 inhibitor adjustment is applied, follow the tazemetostat labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Haloperidol with Tazemetostat?
MediHelp rates the interaction as moderate. Haloperidol and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is metabolized by CYP3A4, and haloperidol can modestly inhibit this enzyme. Higher tazemetostat exposure could increase its adverse effects. The clinical magnitude is likely smaller than with established moderate inhibitors.
How serious is the interaction between Haloperidol and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat toxicity, or choose an antipsychotic without CYP3A4 inhibition. If a labeled CYP3A4 inhibitor adjustment is applied, follow the tazemetostat labeling.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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