Drug interactions
Haloperidol + Temazepam
Severity: Moderate
Haloperidol and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and antipsychotics both depress the CNS, so combined use increases sedation, psychomotor impairment and risk of falls. This is commonly used in practice but needs attention in older or frail patients.
What this interaction means in plain words
Haloperidol and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A enhancement and dopamine and histamine receptor blockade.
What to do
Use the lowest effective doses and monitor sedation and fall risk. Counsel patients on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Haloperidol with Temazepam?
MediHelp rates the interaction as moderate. Haloperidol and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and antipsychotics both depress the CNS, so combined use increases sedation, psychomotor impairment and risk of falls. This is commonly used in practice but needs attention in older or frail patients.
How serious is the interaction between Haloperidol and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and fall risk. Counsel patients on driving and alcohol avoidance.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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