Drug interactions
Haloperidol + Vorinostat
Severity: Moderate
Haloperidol and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat can prolong the QT interval, and haloperidol has a known risk of torsades de pointes. Combined use may increase arrhythmia risk, especially with electrolyte disturbances common in cancer patients.
What this interaction means in plain words
Haloperidol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Check baseline ECG and electrolytes and monitor periodically, correcting potassium and magnesium. Consider an alternative to haloperidol if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Haloperidol with Vorinostat?
MediHelp rates the interaction as moderate. Haloperidol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat can prolong the QT interval, and haloperidol has a known risk of torsades de pointes. Combined use may increase arrhythmia risk, especially with electrolyte disturbances common in cancer patients.
How serious is the interaction between Haloperidol and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor periodically, correcting potassium and magnesium. Consider an alternative to haloperidol if QTc becomes significantly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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