Drug interactions
Haloperidol + Ziconotide
Severity: Moderate
Haloperidol and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally commonly causes dizziness, confusion, sedation and in some cases psychiatric symptoms or psychosis. Haloperidol adds to sedation and may complicate assessment of ziconotide-related neuropsychiatric adverse effects.
What this interaction means in plain words
Haloperidol and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; ziconotide blocks N-type calcium channels while haloperidol blocks dopamine D2 receptors.
What to do
Monitor cognition, mental status and sedation closely, particularly during ziconotide titration. Reduce the ziconotide dose or stop it if neuropsychiatric symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Haloperidol with Ziconotide?
MediHelp rates the interaction as moderate. Haloperidol and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide given intrathecally commonly causes dizziness, confusion, sedation and in some cases psychiatric symptoms or psychosis. Haloperidol adds to sedation and may complicate assessment of ziconotide-related neuropsychiatric adverse effects.
How serious is the interaction between Haloperidol and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition, mental status and sedation closely, particularly during ziconotide titration. Reduce the ziconotide dose or stop it if neuropsychiatric symptoms emerge.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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