Drug interactions
Haloperidol + Zolmitriptan
Severity: Minor
Haloperidol and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported rarely with triptans combined with other psychotropic drugs. With haloperidol the risk is low and largely theoretical.
What this interaction means in plain words
Haloperidol and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Haloperidol belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; mechanism is not well established.
What to do
No routine change is needed; counsel the patient to report agitation, fever, tremor, or rigidity and stop treatment if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Haloperidol with Zolmitriptan?
MediHelp rates the interaction as minor. Haloperidol and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonin syndrome has been reported rarely with triptans combined with other psychotropic drugs. With haloperidol the risk is low and largely theoretical.
How serious is the interaction between Haloperidol and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to report agitation, fever, tremor, or rigidity and stop treatment if serotonin toxicity is suspected.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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