Drug interactions
Hemin + Prednisone
Severity: Moderate
Hemin and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can induce hepatic delta-aminolevulinic acid synthase, the enzyme hemin is meant to suppress in acute porphyria. This may reduce hemin effectiveness and worsen porphyria attacks.
What this interaction means in plain words
Hemin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hemin belongs to Miscellaneous; Prednisone belongs to Endocrine.
Why it happens
Steroid induction of ALA synthase opposes hemin's feedback repression of heme synthesis.
What to do
Avoid unnecessary corticosteroids in acute porphyria and monitor porphyrin precursors and clinical response if they are required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Hemin with Prednisone?
MediHelp rates the interaction as moderate. Hemin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can induce hepatic delta-aminolevulinic acid synthase, the enzyme hemin is meant to suppress in acute porphyria. This may reduce hemin effectiveness and worsen porphyria attacks.
How serious is the interaction between Hemin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary corticosteroids in acute porphyria and monitor porphyrin precursors and clinical response if they are required.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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