Drug interactions
Histrelin + Indacaterol
Severity: Moderate
Histrelin and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and indacaterol can add to QT effects and lower potassium. The combination may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Histrelin and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, as androgen deprivation alters cardiac repolarization and beta-agonists may cause hypokalemia.
What to do
Check ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Indacaterol?
MediHelp rates the interaction as moderate. Histrelin and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and indacaterol can add to QT effects and lower potassium. The combination may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Histrelin and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium abnormalities.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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