Drug interactions
Histrelin + Ondansetron
Severity: Moderate
Histrelin and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can lengthen the QT interval through androgen deprivation, and ondansetron also prolongs QT in a dose-related way. Using both together may raise the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Histrelin and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through pharmacodynamic effects of androgen deprivation and 5-HT3 antagonism on cardiac repolarization.
What to do
Correct potassium and magnesium before starting and obtain an ECG in patients with cardiac risk factors. Prefer a non-QT-prolonging antiemetic in patients with congenital long QT or significant heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Ondansetron?
MediHelp rates the interaction as moderate. Histrelin and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can lengthen the QT interval through androgen deprivation, and ondansetron also prolongs QT in a dose-related way. Using both together may raise the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Histrelin and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting and obtain an ECG in patients with cardiac risk factors. Prefer a non-QT-prolonging antiemetic in patients with congenital long QT or significant heart disease.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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