Drug interactions
Histrelin + Ranolazine
Severity: Moderate
Histrelin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, as a GnRH agonist causing androgen deprivation, may prolong the QT interval. Combined with ranolazine this may increase torsades de pointes risk.
What this interaction means in plain words
Histrelin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QTc prolongation; androgen deprivation therapy is associated with QT prolongation.
What to do
Obtain baseline ECG and electrolytes and monitor QTc periodically. Correct potassium and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Ranolazine?
MediHelp rates the interaction as moderate. Histrelin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, as a GnRH agonist causing androgen deprivation, may prolong the QT interval. Combined with ranolazine this may increase torsades de pointes risk.
How serious is the interaction between Histrelin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and electrolytes and monitor QTc periodically. Correct potassium and magnesium deficits.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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