Drug interactions
Histrelin + Sevoflurane
Severity: Moderate
Histrelin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with GnRH agonists such as histrelin may prolong the QT interval. Sevoflurane may add to this effect, though the clinical risk is modest.
What this interaction means in plain words
Histrelin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with the GnRH agonist effect likely mediated by hormonal changes.
What to do
Check baseline QTc and electrolytes before anesthesia in patients with other QT risk factors. Monitor the ECG during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Sevoflurane?
MediHelp rates the interaction as moderate. Histrelin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with GnRH agonists such as histrelin may prolong the QT interval. Sevoflurane may add to this effect, though the clinical risk is modest.
How serious is the interaction between Histrelin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and electrolytes before anesthesia in patients with other QT risk factors. Monitor the ECG during the procedure.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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