Drug interactions
Histrelin + Sotalol
Severity: Moderate
Histrelin and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, produces androgen deprivation that may prolong the QT interval. With sotalol this may further raise the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
Androgen deprivation therapy may prolong QT, adding to the direct repolarization effects of sotalol.
What to do
Review the need for both drugs and obtain baseline ECG and electrolytes. Monitor QTc periodically during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Sotalol?
MediHelp rates the interaction as moderate. Histrelin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, produces androgen deprivation that may prolong the QT interval. With sotalol this may further raise the risk of torsades de pointes.
How serious is the interaction between Histrelin and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for both drugs and obtain baseline ECG and electrolytes. Monitor QTc periodically during therapy.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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