Drug interactions
Human papillomavirus vaccine + Ibrutinib
Severity: Moderate
Human papillomavirus vaccine and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs B-cell function and may reduce the antibody response to HPV vaccine. Protection may be weaker in patients vaccinated during therapy.
What this interaction means in plain words
Human papillomavirus vaccine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Ibrutinib belongs to Oncology.
Why it happens
Ibrutinib inhibits Bruton tyrosine kinase, reducing B-cell activation and antibody production.
What to do
Complete vaccination before starting ibrutinib when possible; otherwise consider revaccination after therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Human papillomavirus vaccine with Ibrutinib?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs B-cell function and may reduce the antibody response to HPV vaccine. Protection may be weaker in patients vaccinated during therapy.
How serious is the interaction between Human papillomavirus vaccine and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination before starting ibrutinib when possible; otherwise consider revaccination after therapy ends.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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