Drug interactions
Human papillomavirus vaccine + Mechlorethamine
Severity: Moderate
Human papillomavirus vaccine and Mechlorethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a cytotoxic alkylating agent that may impair the immune response to HPV vaccine. Vaccine efficacy may be lower when given during chemotherapy.
What this interaction means in plain words
Human papillomavirus vaccine and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Mechlorethamine belongs to Oncology.
Why it happens
Cytotoxic myelosuppression and lymphocyte depletion reduce vaccine-induced immune response.
What to do
Give the vaccine at least 2 weeks before chemotherapy when possible. Consider revaccination after treatment ends and immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Human papillomavirus vaccine with Mechlorethamine?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a cytotoxic alkylating agent that may impair the immune response to HPV vaccine. Vaccine efficacy may be lower when given during chemotherapy.
How serious is the interaction between Human papillomavirus vaccine and Mechlorethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before chemotherapy when possible. Consider revaccination after treatment ends and immune recovery.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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